Taking Alpha Lipoic Acid for Multiple Sclerosis

Multiple sclerosis is a progressive degenerative disease in which the nerves are disturbed and is caused by a gradual loss of the myelin sheath that surrounds each nerve cell. In essence, the body’s immune system attacks the body’s tissues as if they were foreign proteins. The myelin sheath facilitates the transmission of nerve impulses. As these are lost, nerve function is lost, which results in slow reactionary skills such as walking, talking, dizziness, and vision impairment. The free radicals which damage the nerve cells are reactive molecules that bind to cellular compounds, destroying them. In order for multiple sclerosis to progress, white blood cells must enter the central nervous system. The diagnosis of MS is usually confirmed by the detection of evidence of demyelination on magnetic resonance imaging (MRI). There are several treatment methods used for MS, some considered controversial, and some with a better track record of success than others. One of the bigger problems with treating multiple sclerosis is that it is hard to pinpoint exactly the onset of its introduction into the body, and therefore, difficult to treat. It has been proven that earlier detection is the key to slowing the progression of the disease on sufferers. Alpha lipoic acid for multiple sclerosisis a treatment that is used by thousands of sufferers of MS.

Alpha-lipoic acid, alternately known as alpha-LA) is a vitamin-like substance often referred to as ‘nature’s perfect antioxidant’, so aptly named because it is a very small molecule that is easily absorbed and crosses cell membranes with ease, including the blood brain barrier. Alpha-LA can quench either water or fat soluble free radicals both inside the cell and outside in the intracellular spaces. It also extends the biochemical life of vitamin C and vitamin E and a host of other antioxidants. In regards, to clinical use, alpha-lipoic acid has been used for the treatment of diabetic neuropathy. In Germany, it has been successfully used for over thirty years. The benefits of alpha-LA in diabetic neuropathy have been confirmed in several studies when used at a dosage of between 300 to 600 milligrams daily.

In the treatment of multiple sclerosis, alpha-lipoic acid has the ability to suppress and treat the animal model of MS. On the basis of these observations on animals, further studies have been done, and the initial phase of lesion formation in encephalomyelitis (EAE) reaction oxygen species of free radicals caused damage to the blood barrier (BBB). In normal instances, this protective barrier prevents the passage of large molecules and white blood cells into the central nervous system. Once the blood brain barrier is destroyed or damaged, it leads to the migration of T-lymphocytes and other white blood cells into the central nervous system.

Alpha-LA has proven to prevent the development of clinical signs in EAE in rats through its ability to decrease white blood cell infiltration into the central nervous system. This means that alpha-LA effect increases as the dosage a patient takes increases. Through even more thorough research utilizing state of the art imaging techniques, alpha-LA has shown the ability to inhibit the formation of other compounds associated with promoting inflammation with the central nervous system. Studies have shown that there is a significant dose response relationship between alpha-LA and the adhesion molecule that helps to transport white blood cells into the central nervous system. Therefore, researchers have deduced that alpha-LA is of significant benefit in the fight against the symptoms of multiple sclerosis.

Multiple sclerosis is regarded as a disease with many overlying factors, which means that in order to effectively treat it and stop its progression many different factors must be addressed as soon as possible. The recent studies with alpha lipoic acid for multiple sclerosishave shown that its use can be an extremely useful tool against MS. the dosage that appears to have the best effect is estimated to be around 1200 milligrams a day.

 

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